84-3789-91　ERBB3, phosphorylated (Y1289) 50ug　328611

特徴

• This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases.
• This membrane-bound protein has a neuregulin binding domain but not an active kinase domain.
• It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation.
• However, it does form heterodimers with other EGF receptor family members which do have kinase activity.
• Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation.
• Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors.
• Alternate transcriptional splice variants encoding different isoforms have been characterized.
• One isoform lacks the intermembrane region and is secreted outside the cell.
• This form acts to modulate the activity of the membrane-bound form.
• Additional splice variants have also been reported, but they have not been thoroughly characterized.
• Applications:Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Immunofluorescence: 1:200-1:1000ELISA: 1:10,000Western Blot: 1:500-1:2000Immunohistochemistry: 1:100-1:300Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.