Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma.
Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung.
This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
Applications:Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Immunofluorescence: 1:200-1:1000ELISA: 1:10,000Western Blot: 1:500-1:2000Immunohistochemistry: 1:100-1:300Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human CYSLTR1. Species Crossreactivity: monkey
Isotype：IgG
Calc Applications Abbrev：E IF IHC WB
Calc Crossreactivity：Hu Mk
Immunogen：Synthetic peptide corresponding to the Internal region of human CYSLTR1.
