Adherens junctions (also called AJs and the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces.
AJs mediate adhesion between cells, communicate signals that neighboring cells are present, and anchor the actin cytoskeleton.
In serving these roles, AJs regulate normal cell growth and behavior.
At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia.
This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000ELISA: 1:20,000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human beta-catenin. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic non-phosphopeptide mapping around the T41/S45 phosphorylation site of human Catenin-beta.
