CHOP a transcriptional-regulatory protein of the bZIP family.
Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot bind DNA.
May play an important role in melanoma progression.
CK2-mediated phosphorylation inhibits its transcriptional activity.
Up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform.
Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry/Immunofluorescence.
Other applications not tested.
Recommended Dilution:Western Blot: 1:500-1:2000Immunohistochemistry: 1:50-1:200Immunocytochemistry/Immunofluorescence: 1:100-1:500Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4°C for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes human GADD153. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IC IF IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to human GADD153.
