Human Thyroglobulin (Tg) is a 660kD, dimeric protein produced by and used entirely within the thyroid gland.
Human Thyroglobulin Tg was referred to as 'colloid'.
Human Thyroglobulin (Tg) is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine.
Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against human Thyroglobulin (Tg).
Human Thyroglobulin Tg-specific antibodies help in the diagnosis of these diseases, but they also may be present in apparently healthy euthyroid individuals.
Human Thyroglobulin (Tg) levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer.
Thyroglobulin (Tg) levels in the blood can also be elevated in cases of Graves disease.
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistology: (Formalin/paraffin): 1:125-1:250 for 30 min at RT.
No special pretreatment is required for immunohistochemical staining of formalin/paraffin tissues
Optimal dilutions to be determined by the researcher.
Positive Control:Thyroid
Storage and Stability:May be stored at 4°C for short-term only.
For long-term storage, aliquot and store at -20°C.
Aliquots are stable for at least 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Purified
Purity：Purified.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Specificity：Recognizes human Thyroglobulin. Has been shown to be useful in positive identification of thyroid carcinomas of the papillary and follicular types. Demonstration of thyroglobulin in a metastatic lesion establishes the thyroid origin of the tumor. Adenocarcinomas of non-thyroidal origin are not reactive.
Isotype：IgG
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Purified human thyroglobulin. Cellular Localization: Cytoplasmic MW of Antigen: 330kD
