Metabotropic glutamate receptors are G-protein coupled receptors activated by glutamate.
Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8.
mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells.
mGluRs have been suggested to play a variety of functional roles, among which is involvement in synaptic plasticity underlying learning and memory as well as chronic pain.
Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
Aliquots are stable at -20°C for 12 months after receipt.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Specificity：Recognizes residues 860-872, NGREVVDSTTSSL, of the rat mGlurR2/3 protein.
Isotype：IgG
Calc Applications Abbrev：IC IHC WB
Calc Crossreactivity：Rt
Immunogen：Synthetic peptide corresponding to aa860-872, NGREVVDSTTSSL, of the rat mGlurR2/3 protein. Species Sequence Homology: human and mouse; 100%; conserved between mGluR2 and mGluR3.
