Metabotropic glutamate receptors are G-protein coupled receptors activated by glutamate.
Based on sequence similarity, transduction mechanisms and agonist potencies, mGluRs are subdivided into three groups: mGluR1/mGluR5, mGluR2/mGluR3, and mGluR4/mGluR6/mGluR7/mGluR8.
mGluRs are widely distributed throughout the nervous system and are expressed by both neurons and glial cells.
mGluRs have been suggested to play a variety of functional roles, among which is involvement in synaptic plasticity underlying learning and memory as well as chronic pain.
Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C in the dark.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: APC conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide and a stabilizer. Labeled with Allophycocyanin (APC).
Specificity：Recognizes residues 860-872, NGREVVDSTTSSL, of the rat mGlurR2/3 protein.
Isotype：IgG
Calc Applications Abbrev：IC IHC WB
Calc Crossreactivity：Rt
Immunogen：Synthetic peptide corresponding to aa860-872, NGREVVDSTTSSL, of the rat mGlurR2/3 protein. Species Sequence Homology: human and mouse; 100%; conserved between mGluR2 and mGluR3.
