Vascular endothelial growth factors (VEGFs), a group of structurally and functionally related growth factors, may play important roles in vascular system formation during embryonic development, the regulation of capillary growth in adults, and the maintenance of normal vasculature.
VEGF-C is a ligand for the receptor tyrosine kinases VEGFR-3 and VEGFR, bothof which are expressed by endothelial cells.
VEGF-C mRNA has been detected in human heart, placenta, muscle, ovary, and small intestine, as well as in malignant tissues.
A study of 35 tumor samples detected VEGF-C mRNA expression in over 50% of tumor specimens, including breast carcinomas, squamous cell carcinomas, melanomas, sarcomas, and adenomas, with notable low-level consistency for all lymphomas examined.
VEGF-C has been implicated in lymphangiogenesis, physiological angiogenesis, and the development and progression of angiogenic diseases, including the angiogenesis associated with breast cancers.
Applications:Suitable for use in Western Blot.
Other applications have not been tested.
Recommended Dilution:Western Blot: 1-2ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C in the dark.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: PE conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with R-Phycoerythrin (PE).
Specificity：Recognizes the mature form of human VEGF-C. No cross-reactivity with other species has been detected. On Western blots, this antibody recognizes the mature form of VEGF-C at 21kD, as well as forms of VEGF-C at other points in its proteolytic processing (43 and 58/61kD). Reactivity is confirmed with human PC-3 prostate adenocarcinoma cell lysates.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to the internal region of the human VEGF-C protein.
