84-3654-37　c-Met, CT (Hepatocyte Growth Factor Receptor, Scatter Factor Receptor, HGFR, SFR) (HRP) 100ul　M3007-13-HRP

特徴

• Following its characterization as an activated oncogene (based on its ability to transform normal fibroblasts) Met was characterized as the receptor for hepatocyte growth factor.
• The c-Met receptor is a disulfide bonded heterodimer consisting of an ~50kD extracellular a-chain and an ~145kD b-chain with a cytoplasmic tyrosine kinase domain.
• Both chains are derived from a single precursor protein by proteolytic cleavage.
• c-Met is expressed in a wide variety of adult and embryonic tissues.
• It transmits biological responses including mitogenesis, morphogenesis and anti-apoptotic activity elicited by HGF.
• Dysregulated c-Met gene expression is observed in a variety of human carcinomas and sarcomas.
• c-Met also mediates the movement and invasiveness of neoplastic cells and promotes metastasis.
• Recently, transcription of the c-Met gene was suggested to be a target for regulation by p53.
• Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.