84-3652-19　Claudin 8 (CLDN8) (Biotin) 100ul　C5838-56-Biotin

特徴

• Claudin-8 is a tight junction protein expressed in several mouse distal nephron segments, suggesting that it may contribute to the paracellular barrier that protects transtubular Na+, K+, and H+ gradients in the distal nephron.
• Caludin-8 decreases paracellular permeability to cations when overexpressed in MDCK-II cells, suggesting that it may function as a paracellular cation barrier.
• Caludin-8 is also found in the thin ascending limb of Henle, a segment of the nephron that is known to be leaky to Na+.
• Claudin-8 is expressed primarily in tight junctions along the entire aldosterone-sensitive distal nephron (ASDN) and in the late thin descending limb of Henle, consistent with its role as a paracellular cation barrier protein.
• Claudin-8 is found in umbrella cell tight junctions in the bladder epithelium.
• Expression of Claudin-8 has also been reported in the inner ear.
• Applications:Suitable for use in Immunohistochemistry, Western Blot and Immunofluorescence/Immunocytochemistry.
• Other applications have not been tested.
• Recommended Dilutions:Immunohistochemistry: FrozenOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.