84-3652-06　Aurora C (Serine/threonine-protein kinase 13, Serine/threonine kinase AIE2, Aurora IPL1/Eg2 protein 2, Aurora IPL1-related kinase 3) (Biotin) 100ul　A4190-17C-Biotin

特徴

• Aurora C1 is a member of the aurora/Ipl1p family of protein kinases that are important regulators of mitosis.2 Aurora C is a novel chromosomal passenger protein that, in coordination with Aurora B, regulates mitotic chromosome dynamics in human cells.3,4 Aurora C may play a role in organizing microtubules relating to the function of the centrosome/spindle pole during mitosis, and is localized to the centrosome from anaphase to cytokinesis.5 The expression of Aurora C is maximum at M phase.5 Aurora C is activated by directly associating with inner centromere protein (INCENP).3 Aurora C is expressed in normal testis6, and elevated expression levels are seen in a subset of cancer cells such as HepG2 and HeLa cells.5
• Applications:Suitable for use in Western Blot.
• Other applications have not been tested.
• Recommended Dilution:Western Blot: 1-3ug/mlOptimal dilutions to be determined by the researcher.
• Positive Control:Human placenta homogenates, and human JEG3, HEPG2, HeLa, HEK293, NGP96, SKNEP-1 and U251 cell lysates.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.