Syndecans are heparan sulfate proteoglycans (HSPGs), which are cell-surface-associated proteins.
These include Syndecans.
Syndecans contain a small core protein with distinct functional domains to which are linked multiple glycosaminoglycan (GAG) chains, predominantly of the heparan sulfate variety.
Syndecan synthesis is highly regulated and is dependent on both cell type and developmental state.
Syndecans are involved in cell adhesion, tissue morphogenesis and differentiation and regulation of cell responsiveness to soluble growth-regulatory compounds.
These functions are attributed primarily to the glycan moieties.
Syndecans also interact with growth factors such as fibroblast growth factor and epidermal growth factor.
Applications:Suitable for use in ELISA and Western Blot.