Stem Cell Factor (also known as SCF, kit-ligand, KL, or steel factor) is a cytokine that binds to the c-Kit receptor (CD117).
The SCF gene is mapped to 12q21.32.
SCF can exist both as a transmembrane protein and a soluble protein.
This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis.
SCF may be used along with other cytokines to culture HSCs and hematopoietic progenitors.
The expansion of these cells ex-vivo (outside the body) would allow advances in bone-marrow transplantation, in which HSCs are transferred to a patient to re-establish blood formation.
One of the problems of injecting SCF for therapeutic purposes is that SCF activates mast cells.
The injection of SCF has been shown to cause allergic-like symptoms and the proliferation of mast cells and melanocytes.
UniProt Number:P21583
Gene ID:KITLG
Applications:Suitable for use in FLISA, Western Blot.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C in the dark.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: MaxLight™550 conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™550.
Specificity：Recognizes human SCF. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：FLISA WB
Calc Crossreactivity：Hu
Immunogen：E. coli-derived human SCF recombinant protein (Position: E26-A190).
