TNFα(Tumor Necrosis Factor alpha) gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily.
This cytokine is mainly secreted by macrophages.
It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.
This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.
This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Knockout studies in mice also suggested the neuroprotective function of this cytokine.
UniProt Number:P06804
Gene ID:TNF
Applications:Suitable for use in ELISA, Western Blot, Immunohistochemistry (Paraffin), Neutralization and Immunoprecipitation.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. Labeled with Fluorescein isothiocyanate (FITC).
Specificity：Recognizes mouse TNF alpha. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：E IHC IP N WB
Calc Crossreactivity：Mo
Immunogen：E. coli-derived mouse TNF alpha recombinant protein (Position: L80-L235).
