Stem Cell Factor (also known as SCF, kit-ligand, KL, or steel factor) is a cytokine that binds to the c-Kit receptor (CD117).
The SCF gene is mapped to 12q21.32.
SCF can exist both as a transmembrane protein and a soluble protein.
This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis.
SCF may be used along with other cytokines to culture HSCs and hematopoietic progenitors.
The expansion of these cells ex-vivo (outside the body) would allow advances in bone-marrow transplantation, in which HSCs are transferred to a patient to re-establish blood formation.
One of the problems of injecting SCF for therapeutic purposes is that SCF activates mast cells.
The injection of SCF has been shown to cause allergic-like symptoms and the proliferation of mast cells and melanocytes.
UniProt Number:P21583
Gene ID:KITLG
Applications:Suitable for use in ELISA, Western Blot.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Handling:Store at -20˚C for one year.
After reconstitution, store at 4˚C for one month.
Can also be aliquoted and stored frozen at -20˚C for long term
Avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. Labeled with Biotin.
Specificity：Recognizes human SCF. No crossreactivity with other proteins.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：E. coli-derived human SCF recombinant protein (Position: E26-A190).
