MaxLight™ 405 is a new Violet photostable dye conjugate comparable to Alexa Fluor® 405, PacificBlue™, Brilliant™ Violet 421 and offers better labeling efficiency, brighter imaging and increased immunodetection.
Parkinson's disease (PD) is a multifactorial disease that appears to arise from the effects of both genetic and environmental influences.
The known genetic factors include multiple genes that have been identified in related parkinsonian syndromes, as well as alpha-synuclein.
Genes associated with either PD or Parkinson-related disorders include parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), nuclear receptor-related factor 1 (NURR1), and alpha-synuclein.
Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons.
It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor.
RXR ligands can promote the survival of DA neurons via a process that depends on Nurr1-RXR heterodimers.
In developing DA cells, Nurr1 is required for the expression of several genes important for DA synthesis and function.
Nurr1 is also important for the maintenance of adult DA neurons.
Applications:Suitable for use in FLISA, Western Blot, Immunofluorescence and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C in the dark.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: MaxLight™490 conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A/G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™405.
Specificity：Recognizes human NR4A2.
Isotype：IgG
Calc Applications Abbrev：FLISA IF IHC WB
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 13-42 in the N-terminal region of human NR4A2, UniProt Accession #P43354.
