84-3544-40　［取扱停止］Cortactin (Phospho-Tyr466) (Src Substrate cortactin, Cttn, Ems1) (PE) 100ul　302364-PE

特徴

• Contributes to the organization of the actin cytoskeleton and cell shape.
• Plays a role in the formation of lamellipodia and in cell migration (By similarity).
• Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity).
• Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity).
• Plays a role in focal adhesion assembly and turnover (By similarity).
• In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1- phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity).
• Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane.
• Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity).
• Applications:Suitable for use in Western Blot, Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000Immunohistochemistry: 1:50~100Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C in the dark.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: PE conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.