84-3532-68　［取扱停止］SET07, ID (Histone H4-K20 Methyltransferase, H4-K20-HMTase, SET Domain-containing Protein 8, PR/SET Domain-containing Protein 07, PR/SET07, PR-Set7, KMT5A, Histone-lysine N-methyltransferase SETD8, H4-K20-HMTase SETD8, Lysine N-methyltransferase 5A, PRSET7, SET8) (PE) 200ul　S1012-28F-PE

特徴

• SETD8 is a histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4.
• H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression.
• The protein mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.
• It is required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis.
• It is also involved in chromosome condensation and proper cytokinesis.
• Nucleosomes are preferred as substrate compared to free histones.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:1,000Western Blot: 1:50-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C in the dark.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: PE conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.