84-3501-34　［取扱停止］Synphilin-1, CT (Sph1, Alpha-synuclein-interacting Protein, SNCAIP) (FITC) 200ul　S9116-01C-FITC

特徴

• Parkinson is the second most common neurodegenerative disease after Alzheimers.
• About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease.
• The mutation is the most common cause of Parkinson disease identified to date.
• Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons.
• Mutations of SNCAIP have been linked to Parkinson disease.
• The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain.
• Expression of mouse synphilin-1 in tissues is similar to its human counterpart.
• Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1.
• Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:1,000Western Blot: 1:50-1:100Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: FITC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.