84-3496-41　［取扱停止］AGT, NT (Angiotensinogen, Serpin A8, Angiotensin-1, Angiotensin I, Ang I, Angiotensin-2, Angiotensin II, Ang II, Angiotensin-3, Angiotensin III, Ang III, Des-Asp[1]-angiotensin II, SERPINA8) (FITC) 200ul　A2294-48N-FITC

特徴

• AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure.
• The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II.
• The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia.
• Mutations in AGT gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development.
• Defects in AGT gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
• Applications:Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:ELISA: 1:1,000Western Blot: 1:50-1:100Immunohistochemistry: 1:10-1:50Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: FITC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.