84-3492-10　［取扱停止］Uhrf2 (E3 Ubiquitin-Protein Ligase UHRF2, 632-, NIRF, Np95-like ring Finger Protein, Nuclear Protein 97, Nuclear Zinc Finger Protein Np97, Ubiquitin-like PHD and RING Finger Domain-Containing Protein 2, Ubiquitin-like-Containing PHD and RING Finger Domains Protein 2, Uhrf2, Nirf) (Biotin) 200ul　302828-Biotin

特徴

• E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131 (By similarity).
• E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network.
• Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest.
• Also ubiquitinates PCNP leading to its degradation by the proteasome.
• Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C.
• Aliquots are stable at -20°C for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Note: Applications are based on unconjugated antibody.