Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures).
Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members.
May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1.
May play a role in titin/TTN downstream signaling in muscle cells.
May regulate signaling cascades through ubiquitination.
May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
Adapter that mediates the interaction between TRAF6 and CYLD.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Specificity：Recognizes Sqstm1. Species Crossreactivity: human, mouse
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo
Immunogen：KLH conjugated synthetic peptide corresponding to aa346-379 at the human region of human Phospho-Sqstm1(S351). Species sequence homology: rat
