84-3449-13　［取扱停止］Brd7 (Bromodomain-Containing Protein 7, 75kD bromodomain Protein, Brd7, Bp75) (AP) 200ul　302295-AP

特徴

• Acts both as coactivator and as corepressor.
• May play a role in chromatin remodeling.
• Transcriptional corepressor that down-regulates the expression of target genes.
• Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac).
• Binds to the ESR1 promoter.
• Recruits BRCA1 and POU2F1 to the ESR1 promoter.
• Coactivator for TP53-mediated activation of transcription of a set of target genes.
• Required for TP53-mediated cell-cycle arrest in response to oncogene activation.
• Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters.
• Inhibits cell cycle progression from G1 to S phase (By similarity).
• Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity.
• Induces dephosphorylation of GSK3B at 'Tyr-216'.
• Down-regulates TRIM24- mediated activation of transcriptional activation by AR.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:2000Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.