Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells.
It acts as an inhibitor of TNFRSF6 mediated apoptosis.
A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex.
Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis.
It lacks enzymatic (caspase) activity.
Applications:Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry (Not Tested), ELISA
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Purified
Purity：Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Specificity：Recognizes human CFLAR
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：CFLAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152~182 amino acids from the Center region of human CFLAR.
Shelf Life：1year
Swiss Prot Number：O15519
EU Commodity Code：30021010
商品名：CFLAR, ID (CFLAR, CASH, CASP8AP1, CLARP, MRIT, CASP8 and FADD-like apoptosis regulator, Caspase homolog, Caspase-eight-related protein, Caspase-like apoptosis regulatory protein, Cellular FLICE-like inhibitory protein, FADD-like antiapoptotic molecule 1, Inhibitor of FLICE, MACH-related inducer of toxicity, Usurpin, CASP8 and FADD-like apoptosis regulator subunit p43, CASP8 and FADD-like apoptosis regulator subunit p12) (AP) 200ul
