The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains.
TALE homeobox proteins are highly conserved transcription regulators.
This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter.
In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult.
Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.
Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.
Applications:Suitable for use in Western Blot, ELISA
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Purified
Purity：Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Specificity：Human
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-182 amino acids from the Central region of human TGIF1.
