84-3441-42　［取扱停止］F10, CT (Coagulation Factor X, Stuart Factor, Stuart-Prower Factor, Factor X Light Chain, Factor X Heavy Chain, Activated Factor Xa Heavy Chain) (AP) 200ul　F0019-40-AP

特徴

• F10 is the vitamin K-dependent coagulation factor X of the blood coagulation cascade.
• This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR.
• Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases.
• The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway).
• The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting.
• Applications:Suitable for use in Immunohistochemistry, Flow Cytometry (Not Tested), ELISA and Western Blot.
• Other applications not tested.
• Recommended Dilution:Flow Cytometry (Not Tested): 1:10-1:50Immunohistochemistry (Paraffin): 1:50-1:100Western Blot: 1:1000Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4°C.
• DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.
• Note: Applications are based on unconjugated antibody.