The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption.
This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts.
However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness.
Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.
This gene may be subject to RNA editing.
Applications:Suitable for use in ELISA, Western Blot, Flow Cytometry (Not Tested), and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 1:50-1:100ELISA: 1:1,000Immunohistochemistry: 1:10-1:50Flow Cytometry (Not Tested): 1:10-1:50Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4°C.
DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：200ul
Host：rabbit
Source Antibody：human
Grade：Purified
Purity：Purified by ammonium sulfate precipitation.
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Specificity：Recognizes human CTSK.
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide selected from the Center region of human CTSK (KLH).
