This gene encodes a member of a family of solute transporter proteins.
The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system.
Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors.
Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis.
Alternatively spliced transcript variants of this gene have been identified.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.1ng/lane under reducing conditions
Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute with sterile dH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide. Reconstitute with 200ul sterile dH2O.
Specificity：Recognizes human EAAT2. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human EAAT2 expressed in E. coli. (Position: T461-K574). Species sequence homology: mouse and rat (96%)
Shelf Life：1year
Swiss Prot Number：P43004
EU Commodity Code：30021010
商品名：SLC1A2 (EAAT2, EAA2_HUMAN, Excitatory Amino Acid Transporter 2, Excitotoxic Amino Acid Transporter 2, Glial High Affinity Glutamate Transporter, GLT 1, GLT1, Glutamate Aspartate Transporter II, Glutamate Transporter 1, Glutamate/Aspartate Transporter II, Slc1a2, Sodium Dependent Glutamate Aspartate Transporter 2, Sodium-dependent Glutamate/Aspartate Transporter 2, Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2, Solute Carrier Family 1 Glial High Affinity Glutamate Transporter Member 2, Solute Carrier Family 1 Member 2) 100ug
