SYCP3, also known as COR1 or SCP3, is a protein that in humans is encoded by the SYCP3 gene.
It is mapped to 12q23.2.
This gene encodes an essential structural component of the synaptonemal complex.
This complex is involved in synapsis, recombination and segregation of meiotic chromosomes.
Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females.
Alternate splicing results in multiple transcript variants that encode the same protein.
SYCP3 has an essential meiotic function in human spermatogenesis that is compromised by the mutant protein by dominant-negative interference.
SYCP3 is linked to inherited aneuploidy in female germ cells and provides a model system for studying age-dependent degeneration in oocytes.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/ml, detection limit is ~0.25ng/lane under reducing conditions
Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute with sterile dH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder in 0.2mg Na2HPO4, 5mg BSA, 0.9mg sodium chloride, 0.05mg sodium azide. Reconstitute with 200ul sterile dH2O to 0.5mg/ml.
Specificity：Recognizes human SCP3.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human SCP3 expressed in E. coli. (Position: E18-E223). Species sequence homology: mouse (72%) and rat (73%)
