84-3434-78　SAP97 (DLG1, Disks Large Homolog 1, Synapse-associated Protein 97) 100ug　303583

特徴

• Disks large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a protein that in humans is encoded by the SAP97 gene.
• SAP97 is expressed throughout the body in epithelial cells, including the kidney and brain.
• There is some evidence that SAP97 regulates cell-to-cell adhesion during cell death, and may interact with HPV.
• In the brain, SAP97's function is involved in the trafficking of transmembrane receptors from the ER to the plasma membrane.
• SAP97's function has been investigated by reducing its expression by knockout or increasing its expression heterologously.
• Mice in which the SAP97 gene has been knocked out die perinatally, have a cleft palate, and deficiencies in renal function.
• Overexpression of SAP97 in mammalian neurons leads to increased synaptic strength.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/ml, boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.