84-3434-75　RTN3, CT (ASYIP, Neuroendocrine Specific Protein Like 2, Neuroendocrine-specific Protein-like 2, Neuroendocrine-specific Protein-like II, NSP Like Protein II, NSP-like Protein 2, NSP-like Protein II, NSPL2, NSPLII, Reticulon 3, Reticulon-3, Reticulon3, Rtn3, RTN3_HUMAN) 100ug　303580

特徴

• Reticulon-3, also known as RTN3 or NSPL2, is a protein that in humans is encoded by the RTN3 gene.
• It is mapped to 11q13, which is between markers D11S4535 and D11S4627.
• This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues.
• This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta.
• RTN3 colocalized with BACE1 in neurons of human brain gray matter, and overexpression of RTN3 in vitro inhibited BACE1 activity and decreased amyloid precursor protein processing.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 0.1-0.5ug/mlImmunohistochemistry (Paraffin): 0.5-1ug/ml, boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 minutes is required for the staining of formalin/paraffin sections
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.