84-3434-60　PTPN2 (TCPTP, Protein Tyrosine Phosphatase, Non-receptor Type 2, Tyrosine-protein Phosphatase Non-receptor Type 2) 100ug　303563

特徴

• TCPTP is also called as PTPN2.
• The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family.
• Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity.
• PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
• Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling.
• Multiple alternatively spliced transcript variants encoding different isoforms have been found.
• Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/ml, boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.