Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene.
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families.
It is mapped to 12p11.21.
PKP2 is a constituent of the desmosomal plaque in simple epithelia, some stratified epithelia, and some nonepithelial cells.
PKP2 is also enriched in the karyoplasm of cells of various types, including those lacking desmosomes.
Plakophilin proteins participate in linking cadherins to intermediate filaments in the cytoskeleton and this gene product may regulate the signaling activity of beta-catenin.
PKP2 has been shown to interact with Desmoplakin, Plakoglobin and Desmoglein 1.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months at -20°C.
Reconstitute with sterile dH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with 200ul sterile dH2O.
Specificity：Recognizes human Plakophilin 2. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Synthetic peptide corresponding to aa863-881, KKTDFVNSRTAKAYHSLKD, from human Plakophilin 2 at C-terminus, identical to the related mouse sequence, and different from the related rat sequence by 1aa.
