84-3434-16 PARK7 (CAP1, DJ 1, DJ-1, DJ1, DJ1 Protein, Oncogene DJ1, Park 7, Park7, PARK7_HUMAN, Parkinson Disease (Autosomal Recessive Early Onset) 7, Parkinson Disease (Autosomal Recessive, Early Onset) 7, Parkinson Disease Protein 7, Parkinson Protein 7, Protein DJ 1, Protein DJ-1, RNA Binding Protein Regulatory Subunit, RS, SP22) 100ug 303512
84-3434-16 PARK7 (CAP1, DJ 1, DJ-1, DJ1, DJ1 Protein, Oncogene DJ1, Park 7, Park7, PARK7_HUMAN, Parkinson Disease (Autosomal Recessive Early Onset) 7, Parkinson Disease (Autosomal Recessive, Early Onset) 7, Parkinson Disease Protein 7, Parkinson Protein 7, Protein DJ 1, Protein DJ-1, RNA Binding Protein Regulatory Subunit, RS, SP22) 100ug 303512
Parkinson disease (autosomal recessive, early onset) 7, also known as DJ1, is a protein which in humans is encoded by the PARK7 gene.
PARK7 belongs to the peptidase C56 family of proteins.
PARK7 is mapped to chromosome 1p36.
It acts as a positive regulator of androgen receptor-dependent transcription.
It is also involved in tumorigenesis and in maintaining mitochondrial homeostasis.
This gene may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death.
It has been found that PARK7 mutations that impair transcriptional coactivator function can render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of Parkinson disease.
Applications:Suitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.1ng/lane under reducing conditions
Immunohistochemistry (paraffin): 0.5-1ug/ml, boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections
Immunocytochemistry: 0.5-1ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide. Reconstitute with 200ul sterile dH2O.
Specificity：Recognizes human PARK7. Species Crossreactivity: mouse and rat
Isotype：IgG
Calc Applications Abbrev：IC IHC WB
Calc Crossreactivity：Hu Mo Rt
Immunogen：Recombinant protein corresponding to human PARK7 expressed in E. coli. (Position: A2-D189). Species sequence homology: mouse and rat (91%)
