84-3434-10　p27KIP1 (Cdki1b, CDKN 1B, CDKN 4, CDKN1B, CDKN4, CDN1B_HUMAN, Cyclin Dependent Kinase Inhibitor 1B, Cyclin Dependent Kinase Inhibitor p27, Cyclin-dependent Kinase Inhibitor 1B (p27, Kip1), Cyclin-dependent Kinase Inhibitor 1B, Cyclin-dependent Kinase Inhibitor p27, Cyclin-dependent Kinase Inhibitor p27 Kip1, KIP 1, KIP1, MEN1B, MEN4, p27, p27 Kip1, P27-like Cyclin-dependent Kinase Inhibitor, P ...　303506

特徴

• Cyclin-dependent kinase inhibitor 1B (p27KIP1), also known as KIP1 or P27, is an enzyme inhibitor that in humans is encoded by the CDKN1B gene.
• It encodes a protein which belongs to the Cip/Kipfamily of cyclin dependent kinase (Cdk) inhibitor proteins.
• It is mapped to 12p13.1.
• p27KIP1 can inhibit both CDK activation and the kinase activity of assembled and activated cyclin-CDK.
• The function of p27KIP1 is associated with an aggressive phenotype in human breast cancer.
• Downregulation of p27KIP1 by CK2-alpha-prime is necessary for development of agonist- and stress-induced cardiac hypertrophy.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.25ng/lane under reducing conditions
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.