84-3433-83　NCOA1 (SRC1, KAT13A, ASV, C SRC, Class E Basic Helix-loop-helix Protein 74, F SRC 1, Hin 2 Protein, Hin2 Protein, MNRC 1, NCoA 1, NCoA-1, Ncoa1, NCOA1_HUMAN, Nuclear Receptor Coactivator 1, Nuclear Receptor Coactivator Protein 1, NY REN 52 Antigen, P60 Src, Pp60c Src, Protein Hin 2, Protein Hin-2, Protein Hin2, Proto Oncogene Tyrosine Protein Kinase Src, Renal Carcinoma Antigen NY REN 52, Rena ...　303475

特徴

• The nuclear receptor coactivator 1 (NCOA1), also known as SRC1, is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity.
• NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors.
• NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription.
• Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.
• It has been found that NCOA1 can enhance the transcriptional activity of ligand-bound PGR but does not alter the basal activity of the target promoter.
• It also enhances estrogen receptor, glucocorticoid receptor, thyroid hormone receptor, and retinoid X receptor transcriptional activities through their cognate DNA response elements in the presence of hormone.
• SRC1 may play a role as a bridging molecule between nuclear hormone receptors and general transcription factors.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.