84-3433-63　Met (C-Met, AUTS9, C Met, Cmet, Hepatocyte Growth Factor Receptor, Hepatocyte Growth Factor Receptor Precursor, HGF, HGF Receptor, HGF SF Receptor, HGF/SF Receptor, HGFR, MET, Met Proto Oncogene Tyrosine Kinase, MET Proto Oncogene, Receptor Tyrosine Kinase, Met Proto-oncogene (Hepatocyte Growth Factor Receptor), Met Proto-oncogene, Met Protooncogene, MET_HUMAN, Oncogene MET, Par4, Proto-oncoge ...　303453

特徴

• c-Met, also called MET and hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.
• It is mapped to 7q31.2.
• The protein possesses tyrosine kinase activity.
• MET is a membrane receptor that is essential for embryonic development and wound healing.
• It induces several biological responses that collectively give rise to a program known as invasive growth.
• MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain.
• Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult.
• However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of cancer persistence and spread to other sites in the body.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.25ng/lane under reducing conditions
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.