84-3433-61　MERTK, NT (C MER, C Mer Proto Oncogene Tyrosine Kinase, C-mer, cMER, Cmer Protooncogene Tyrosine Kinase, Eyk, MER, MER Receptor Tyrosine Kinase, MERK, MERPEN, Mertk, MERTK C-mer Proto-oncogene Tyrosine Kinase, Nmf12, Nyk, Proto Oncogene Tyrosine Protein Kinase MER, Proto Oncogene Tyrosine Protein Kinase MER Precursor, Proto-oncogene c-Mer, Receptor Tyrosine Kinase MerTK, RP38, STK Kinase, Tyro ...　303450

特徴

• Proto-oncogene tyrosine-protein kinase MER, also called MERTK is an enzyme that in humans is encoded by the MERTK gene.
• This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain.
• This gene is mapped to 2q13.
• MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment.
• This gene is also very important in inhibition of Toll-like receptors(TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.