84-3433-44　LKB1 (HLKB1, Liver Kinase B1, LKB 1, NY REN 19 Antigen, Peutz Jeghers Syndrome, PJS, Polarization Related Protein LKB1, Renal Carcinoma Antigen NY-REN-19, Serine/Threonine Kinase 11, Serine/Threonine Protein Kinase 11, Serine/Threonine Protein Kinase LKB1, Serine/Threonine Protein Kinase STK11, Serine/Threonine-protein Kinase 11, Serine/Threonine-protein Kinase LKB1, Serine/Threonine-protein K ...　303429

特徴

• Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene.
• The STK11 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumor suppressor.
• STK11 is a primary upstream kinase of adenine monophosphate-activated protein kinase (AMPK), a necessary element in cell metabolism that is required for maintaining energy homeostasis.
• It has been found that LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways.
• The STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere direction.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.25ng/lane under reducing conditions
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.