84-3432-76　HEF1 (CAS L, Cas Like Docking, Cas Scaffolding Protein Family Member 2, CAS-L, CAS2, CASL, CASL_HUMAN, CASS2, Crk Associated Substrate Related, Crk Associated Substrate Related Protein, CRK-associated Substrate-related Protein, Enhancer of Filamentation 1, Enhancer of Filamentation 1 p55, HEF 1, NEDD 9, NEDD-9, NEDD9, NEDD9 Protein, Neural Cell Expressed Developmentally Down Regulated 9, Neura ...　303351

特徴

• Enhancer of filamentation 1 (EF1), also known as NEDD-9, is a protein that in humans is encoded by the NEDD9 gene.
• The protein encoded by this gene is a member of the CRK-associated substrates family.
• Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways.
• It is mapped to 6p24.2.
• This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle.
• This protein has also been reported to have a role in cancer metastasis.
• NEDD9 is also a highly relevant cancer gene that governs metastatic potential in human melanoma.
• It has been speculated that NEDD9 may be an important linking element between extracellular signaling and regulation of the cytoskeleton.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.1ng/lane under reducing conditions
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.