84-3432-42　FOXO3A (FKHR2, FKHRL 1, FKHRL1, FKHRL1P2, Forkhead (Drosophila) Homolog (Rhabdomyosarcoma) Like 1, Forkhead Box O3, Forkhead Box O3A, Forkhead Box Protein O3, Forkhead Box Protein O3A, Forkhead Drosophila Homolog of in Rhabdomyosarcoma Like 1, Forkhead Homolog (Rhabdomyosarcoma) Like 1, Forkhead in Rhabdomyosarcoma Like 1, Forkhead in Rhabdomyosarcoma-like 1, FOX O3A, FOXO2, Foxo3) 100ug　303313

特徴

• Forkhead box O3, also known as FKHRL1 or FOXO3a, is a human protein encoded by the FOXO3 gene.
• FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain.
• It is mapped to 6q21.
• This protein likely functions as a trigger for apoptosis through upregulation of genes necessary for cell death, such as Bim and PUMA, or downregulation of anti-apoptotic proteins such as FLIP.
• In mammals FOXO3 regulates the resistance of cells to stress by inducing DNA repair and thereby may also affect organismal life span.
• In addition, it is thought that FOXO3 is also involved in protection from oxidative stress by upregulating antioxidants such as catalase and MnSOD.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/ml, boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.