Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene.
It is mapped to 12p13.33.
The protein encoded by this gene is a member of the FOX family of transcription factors.
FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation.
FOXM1 gene is now known as a human proto-oncogene.
Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide.
It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion.
FOXM1 has been shown to modulate the epigenome.
It was found that overexpression of FOXM1 "brain washes" normal cells to adopt cancer-like epigenome.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.25ng/lane under reducing conditions
Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide. Reconstitute with 200ul sterile dH2O.
Specificity：Recognizes human FOXM1.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human FOXM1 expressed in E. coli. (Position: A411-Q763). Species sequence homology: mouse (75%) and rat (76%)
