Chemokine receptor CXCR3 is a Galphai protein-coupled receptor in the CXC chemokine receptor family.
Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183.
It is mapped to Xq13.1.
CXCR3 is expressed on malignant B cells from chronic lymphoproliferative disorders, particularly in patients with CLL, and represents a fully functional receptor involved in chemotaxis of malignant B lymphocytes.
It is found that in the absence of known etiologic agents, CXCR3 represents a novel target for therapeutic interference early in type 1 diabetes.
CXCR3 signaling is associated with MG pathogenesis and proposed that and CXCR3 may serve as novel drug targets to treat MG.
CXCR3A and CXCR3B are involved in the chemotactic and vascular effects of CXCL4L1.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.25ng/lane under reducing conditions
Immunohistochemistry (paraffin): 0.5-1ug/ml, boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections
Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide. Reconstitute with 200ul sterile dH2O.
Specificity：Recognizes human CXCR3. Species Crossreactivity: rat
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu Rt
Immunogen：Recombinant protein corresponding to human CXCR3 expressed in E.coli. (Position: M1-L368). Species sequence homology: mouse and rat (86%)
Shelf Life：1year
Swiss Prot Number：P49682
EU Commodity Code：30021010
商品名：CXCR3 (C-X-C Chemokine Receptor Type 3, CD 183, CD182, CD183, Chemokine (C X C Motif) Receptor 3, Chemokine (C X C) Receptor 3, Chemokine CXC Motif Receptor 3, CKR L2, CKR-L2, CKRL2, CMKAR3, CXC-R3, CXCR-3, G Protein Coupled Receptor 9, G Protein-coupled Receptor 9, GPR9, Interferon-inducible Protein 10 Receptor, IP-10 Receptor, IP10, IP10 R, IP10 Receptor, IP10-R, IP10R, Mig R, Mig Receptor, Mig-R, MIGR) 100ug
