The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration.
It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs).
This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis.
Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined.
Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
Applications:Suitable for use in Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/mlImmunohistochemistry (paraffin): 0.5-1ug/ml, boiling the paraffin sections in 10mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections
Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide. Reconstitute with 200ul sterile dH2O.
Specificity：Recognizes human CD44.
Isotype：IgG
Calc Applications Abbrev：IHC WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa29-56, RFAGVFHVEKNGRYSISRTEAADLCKAF, from human CD44 at N-terminus, different from the related mouse and rat sequences by 2aa.
Shelf Life：1year
Swiss Prot Number：P16070
EU Commodity Code：30021010
商品名：CD44, NT (LHR, BA-1, CD 44, CD44 Antigen, CD44 Isoform RC, CD44 Molecule (Indian Blood Group), CD44 Molecule, CD44_HUMAN, CDw44, Cell Surface Glycoprotein CD44, Chondroitin Sulfate Proteoglycan 8, CSPG8, ECM III, ECMR III, ECMR-III, ECMRIII, Epican, Extracellular Matrix Receptor III, GP90 Lymphocyte Homing Adhesion Receptor, GP90 Lymphocyte Homing/Adhesion Receptor, HCAM, HCELL, Hematopoietic Cell E- and L-selectin Ligand, Heparan Sulfate Proteoglycan, Hermes Antigen, Homing Function and Indian Blood Group System, HSA, HUTCH I, HUTCH-I, HUTCH1, Hyaluronate Receptor, IN, Indian Blood Group, Inlu Related p80 Glycoprotein, lhr, Ly 24, MC56, MDU2, MDU3, MIC4, MUTCH I, MUTCH1, PGP 1, PGP-1, PGP-I, PGP1, Phagocytic Glycoprotein 1, Transmembrane Glycoprotein) 100ug
