84-3431-09　C-Abl, CT (Abelson Murine Leukemia Viral Oncogene Homolog 1, Abelson Murine Leukemia Viral V Abl Oncogene Homolog 1, Abelson Tyrosine Protein Kinase 1, Abl 1, ABL, Abl Protein, ABL Proto Oncogene 1 Non Receptor Tyrosine Kinase, Abl1, ABL1_HUMAN, Bcr/Abl, Bcr/C Abl Oncogene Protein, C Abl Oncogene 1 Non Receptor Tyrosine Kinase, C Abl Oncogene 1 Receptor Tyrosine Kinase, JTK 7, JTK7, P150, Prot ...　303160

特徴

• c Abl is also called as ABL1.
• This gene is a proto oncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress.
• The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene.
• The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function.
• This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene.
• Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.