84-3430-79　ARG1, NT (A I, Al, ARG 1, ARGI1_HUMAN, Arginase 1, Arginase Liver, Arginase Type I, Arginase-1, Arginase1, Liver Type Arginase, Liver-type Arginase, Type I Arginase) 100ug　303128

特徴

• ARG1 (arginase, live) is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle.
• The isoform encoded by ARG1, referred to as the liver, or A-I, isoform, contributes 98% of the arginase activity in liver but is also present in red cells.
• Using a rat liver ARG1 cDNA clone to probe a human liver cDNA library, Haraguchi et al.
• (1987) isolated and characterized a cDNA corresponding to the ARG1 gene.
• The ARG1 gene is mapped on 6q23.2 and the arginase gene contains 8 exons.
• By immunologic studies, 90% of the arginase in red blood cell and liver was precipitated by the antibody, whereas only 50% of the arginase in kidney, brain, and the gastrointestinal tract reacted with it.
• Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia.
• Two transcript variants encoding different isoforms have been found for this gene.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months at -20°C.
• Reconstitute with sterile dH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.