The protein encoded by this gene binds to the beta-amyloid precursor protein.
Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease.
In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein.
This protein is required for cell cycle progression through the S/M checkpoint.
Three transcript variants encoding different isoforms have been found for this gene.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.1ng/lane under reducing conditions
Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size:100ug
Host:rabbit
Source Antibody:human
Grade:Affinity Purified
Purity:Purified by immunoaffinity chromatography.
Form:Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide. Reconstitute with 200ul sterile dH2O.
Specificity:Recognizes human APPBP1. Species Crossreactivity: mouse and rat
Isotype:IgG
Calc Applications Abbrev:WB
Calc Crossreactivity:Hu Mo Rt
Immunogen:Recombinant protein corresponding to human APPBP1 expressed in E. coli. (Position: E181-L534). Species sequence homology: mouse (98%)
Shelf Life:1year
Swiss Prot Number:Q13564
EU Commodity Code:30021010
商品名:APPBP1 (59kD, Amyloid beta Precursor Protein Binding Protein 1 59kD, Amyloid beta Precursor Protein Binding Protein 1 59kD, Amyloid beta Precursor Protein Binding Protein 1, Amyloid beta Precursor Protein-binding Protein 1, Amyloid Protein Binding Protein 1, Amyloid Protein-binding Protein 1, APP BP1, APP-BP1, APPBP 1, HPP 1, HPP1, NAE 1, NAE1, NEDD8 Activating Enzyme E1 Regulatory Subunit, NEDD8 Activating Enzyme E1 Subunit 1, NEDD8 Activating Enzyme E1 Subunit, NEDD8-activating Enzyme E1 Regulatory Subunit, Proto Oncogene Protein 1, Proto-oncogene Protein 1, Protooncogene Protein 1, Ula 1, ULA1_HUMAN) 100ug