84-3430-75　APH1A, CT (Anterior Pharynx Defective 1, Anterior Pharynx Defective 1 Homolog A, APH 1A, Aph 1alpha, APH-1a, Aph-1alpha, Aph1a, APH1A gamma Secretase Subunit, APH1A_HUMAN, CGI 78, CGI78, Gamma Secretase Subunit APH 1A, Gamma Secretase Subunit APH1a, Gamma-secretase Subunit APH-1A, Likely Ortholog of C. elegans Anterior Pharynx Defective 1A, Presenilin Stabilization Factor, Presenilin-stabiliza ...　303123

特徴

• APH1a encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein.
• The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins.
• The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing.
• Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease.
• Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.1ng/lane under reducing conditions
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Lyophilized powder may be stored at -20°C.
• Stable for 12 months after receipt at -20°C.
• Reconstitute with sterile ddH2O.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Reconstituted product is stable for 12 months at -20°C.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Further dilutions can be made in assay buffer.