84-3430-45 ABCG5, NT (ABCG5_HUMAN, ATP Binding Cassette Sub Family G (White) Member 5 (Sterolin 1), ATP Binding Cassette Sub Family G Member 5, ATP-binding Cassette Sub-family G Member 5, Sterolin 1, Sterolin-1, STSL) 100ug 303090
84-3430-45 ABCG5, NT (ABCG5_HUMAN, ATP Binding Cassette Sub Family G (White) Member 5 (Sterolin 1), ATP Binding Cassette Sub Family G Member 5, ATP-binding Cassette Sub-family G Member 5, Sterolin 1, Sterolin-1, STSL) 100ug 303090
ABCG5 (Atp-binding cassette, subfamily g, member 5), also known as Sterolin 1, is a protein that in humans is encoded by the ABCG5 gene.
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.
This protein is a member of the White subfamily.
The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols.
The ABCG5 gene contains 13 exons and spans about 28kb.
The ABCG5 gene is mapped on 2p21.
It is expressed in a tissue-specific manner in the liver, colon, and intestine.
This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8.
Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.
Small (2003) reviewed the role of ABC transporters in secretion of cholesterol from liver into bile, particularly the role of ABCG5/ABCG8.
The ABCG5 and ABCG8 genes are an example of closely neighboring genes in a head-to-head orientation that, when mutated, cause the same phenotype.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot: 0.1-0.5ug/ml, the detection limit is ~0.1ng/lane under reducing conditions
Optimal dilutions to be determined by the researcher.
Storage and Stability:Lyophilized powder may be stored at -20°C.
Stable for 12 months after receipt at -20°C.
Reconstitute with sterile ddH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20°C.
Reconstituted product is stable for 12 months at -20°C.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
Host：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by immunoaffinity chromatography.
Form：Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% sodium azide. Reconstitute with 200ul sterile dH2O.
Specificity：Recognizes human ABCG5.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to aa197-221, ERRRVSIAAQLLQDPKVMLFDEPTT, from human ABCG5 at N-terminus, different from the related mouse and rat sequences by 2aa.
