84-3428-74　RNF7 (RING-box Protein 2, Rbx2, CKII beta-Binding Protein 1, CKBBP1, RING Finger Protein 7, Regulator of cullins 2, Sensitive to Apoptosis gene Protein, RNF7, RBX2, ROC2, SAG) 200ul　302710

特徴

• Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription.
• Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate.
• Promotes the neddylation of CUL5 via its interaction with UBE2F.
• May play a role in protecting cells from apoptosis induced by redox agents.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Western Blot: 1:8000Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4°C for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20°C.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.